Evaluation of the Quantitative Cytological Changes
in the Epithelium of the Uterine Cervix
Yordanka Gluhcheva* , Svetlana Christova**
*Institute of Experimental Morphology and Anthropology, 1113 Sofia
**Department of Clinical Pathology, Medical University - Sofia
Abstract: The cytological investigation is a subjective method which
does not allow to determine accurately the morphological changes of the epithelium
cells, therefore additional diagnostic methods must be used. Such a method is
the Quantitative DNA Analysis. We used the obtained results for statistical
processing in order to deternime whether there is a significant difference between
the cell populations with different degrees of dysplasia and in cases of carcinoma
of the uterine cervix. No such differences were registered between the diploid
cells in phases of DNA presynthesis and synthesis. Significant difference was
calculated when we compared aneuploid cells. This means that cell populations
with different degrees of dysplasia can be distinguished by the aneuploid cells in the smear.
Keywords: dysplasia/cancer, quantitative DNA analysis,
diploid/aneuploid cells, histogram, statistics.